Premium
Parenteral 20% Safflower Oil Emulsion Safety and Effectiveness as a Caloric Source in Newborn Infants
Author(s) -
Marchildon Michael B.
Publication year - 1982
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/014860718200600125
Subject(s) - parenteral nutrition , emulsion , medicine , caloric theory , safflower oil , caloric intake , adverse effect , anesthesia , fat emulsion , body weight , zoology , surgery , chemistry , biochemistry , biology
Five surgical infants, ages 3 to 30 days, were studied while receiving peripheral total parenteral nutrition for a period of 2 weeks. By a randomized sequence, either 10 or 20% safflower oil emulsion was infused the first week, followed by the alternate solution during the second week. Caloric intake was 80 to 100 cal/kg/day, of which lipids comprised one‐third to one‐half. No adverse side effects were noted. Eosinophilia developed in three patients, but otherwise no changes in hematologic and biochemical parameters, including liver enzymes, were noted. Weight gain averaged 11.1 g/kg/day during the study period and was similar for the 10 and 20% solutions. Intravenous fluid intake averaged 21 ml/kg/day less during the week the patients received 20% lipid emulsion. The 20% safflower oil emulsion proved comparable to the 10% solution in both safety and efficacy and enabled significant reduction of fluid intake while maintaining infused caloric levels.