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Plasma Fatty Acid Patterns of Bone Marrow Transplant Patients Primarily Supported by Fat‐Free Parenteral Nutrition
Author(s) -
Clemans Gordon W.,
Yamanaka William,
Flournoy Nancy,
Aker Saundra N.,
Thomas E. Donnall,
Hutchinson Martha L.,
Cheney Carrie
Publication year - 1981
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607181005003221
Subject(s) - medicine , parenteral nutrition , bone marrow , gastroenterology , endocrinology
Oral food tolerance is compromised by drug and radiation therapy administered to patients undergoing bone marrow transplantation for hematological malignancy or aplastic anemia. Resultant decreases in oral fat intake coincident with fat‐free parenteral nutrition may predispose patients to essential fatty acid (EFA) deficiency. Determinations were made of the fatty acid composition of plasma total lipid from 20 bone marrow transplant patients on admission, at the time of bone marrow transplant, and on days 7, 14, 30, and 60 post‐bone marrow transplant. Patients ate ad libitum but with little appetite and received fat‐free parenteral nutrition interrupted for numerous blood product and drug infusions. Abnormal EFA status was manifest (20:3ω9/20:4 ratio>0.2) in 12 of 20 patients during the course of treatment. Plasma EFA status was consistently correlated with oral fat intake but not with sex, age, percentage of ideal body weight, or amount of plasma infused. This suggests that dietary fat was absorbed limiting the severity of EFA deficiency. Interruptions of glucose infusion averaging only about 2 hours/day, also may have helped moderate the deficiency.