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Low Plasma Cortisol and Hematologic Abnormalities Associated With Essential Fatty Acid Deficiency in Man
Author(s) -
Bistrian Bruce R.,
Bothe Albert,
Blackburn George L.,
Defriez Albert I.
Publication year - 1981
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607181005002141
Subject(s) - glucocorticoid , medicine , endocrinology , neutropenia , eosinophilia , fatty acid , adrenal insufficiency , essential fatty acid , biology , polyunsaturated fatty acid , biochemistry , chemotherapy
A case of probable adrenal insufficiency (glucocorticoid only) with hematologic changes including eosinophilia, neutropenia, and red blood cell abnormalities developed in the course of prolonged, fat‐free feeding. The coincident development of essential fatty acid deficiency was confirmed by serum fatty acid profiles indicating the presence of abnormal amounts of eicosatrienoic acid, and a triene/tetraene ratio >0.4; all these findings responded to fat repletion. The association of glucocorticoid deficiency, neutropenia, and eosinophilia with essential fatty acid deficiency has not been previously reported in humans.