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Selenium Supplementation in Total Parenteral Nutrition
Author(s) -
Van Rij Andre M.,
Mckenzie Joan M.,
Thomson Christine D.,
Robinson Marion F.
Publication year - 1981
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607181005002120
Subject(s) - parenteral nutrition , selenium , glutathione peroxidase , urinary system , medicine , excretion , chemistry , glutathione , biochemistry , enzyme , organic chemistry
Four adult patients with very low plasma selenium (Se) levels (≤1.5 μg/100 ml) were given Se supplements while receiving total parenteral nutrition. A comparison was made using the compounds selenomethionine and sodium selenite given either intravenously or by mouth. Urinary excretion and Se plasma responses differed, and indicated that selenomethionine retention was greater. However, the incorporation of Se into the erythrocyte and its enzyme glutathione peroxidase was unpredictable and delayed and was not a good indicator of supplement response. No deleterious effects of supplements were observed. Se supplements are indicated especially in patients with a high risk of developing low Se levels and are best monitored by plasma Se levels.