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Clinical Effectiveness of a Pancreatic Enzyme Supplement
Author(s) -
Valerio David,
Whyte Eric H.A.,
Schlamm Haran T.,
Ruggiero John A.,
Blackburn George L.
Publication year - 1981
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607181005002110
Subject(s) - microsphere , placebo , gastroenterology , medicine , pancreatic enzymes , feces , enzyme , weight gain , digestive enzyme , endocrinology , body weight , chemistry , pancreas , biology , biochemistry , amylase , pathology , microbiology and biotechnology , alternative medicine , chemical engineering , engineering
In 23 adult patients with pancreatic insufficiency, we evaluated the efficacy of a pancreatic enzyme delivered as pH‐sensitive enteric‐coated pancrelipase microspheres, and compared it with placebo and other available enzyme supplements. In a short‐term study, fecal fat was 23.5 ± 7 g/day with the microspheres, compared with 29.9 ± 8 with other supplements, providing fat utilization of 76 ± 7% versus 63 ± 10% (p < 0.05). Microspheres reduced daily stool frequency to 1.9 movements from 4.3 on other enzymes (p < 0.01). These results were obtained with an average intake of 10 microsphere capsules/day. In a year‐long study of 22 patients, an average weight gain of 4.0 ± 1.1 kg was observed associated with return of near‐normal social and work life‐style in previously housebound patients.