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Hyperalimentation in Primates. A Nutritional Model
Author(s) -
Hobbs Charles L.,
Mullen James L.,
Gertner Marc H.,
Buzby Gordon P.,
Rosato Ernest F.
Publication year - 1980
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/014860718000400501
Subject(s) - parenteral nutrition , macaque , transferrin , nitrogen balance , medicine , primate , physiology , body weight , catheter , albumin , rhesus macaque , nonhuman primate , biology , surgery , immunology , chemistry , paleontology , organic chemistry , neuroscience , nitrogen , evolutionary biology
To establish the subhuman primate as an effective laboratory animal in parenteral nutrition research, 18 male macaque monkeys were adapted to chronic chair restraint and maintained on intravenous nutrition for 1‐ and 2‐week periods. The animals remained in the restraint chairs for 11.6 ± (2.3) weeks, and the inferior vena cava catheters remained for 53 ± (7.8) days. Catheter and metabolic complications during intravenous nutrition infusion were few and morbidity was low. The animals maintained weight, serum albumin, and serum transferring levels as well as a positive nitrogen balance during the study period. The macaque is a highly suitable model for nutritional studies requiring a controlled environment during long‐term studies.