Premium
Supplemental Arginine Increases Thymic Cellularity in Normal and Murine Sarcoma Virus‐inoculated Mice and Increases the Resistance to Murine Sarcoma Virus Tumor
Author(s) -
Rettura Giuseppe,
Padawer Jacques,
Barbul Adrian,
Levenson Stanley M.,
Seifter Eli
Publication year - 1979
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/014860717900300601
Subject(s) - virus , sarcoma , inoculation , virology , neoplasm , biology , pathology , medicine , cancer research
Arginine supplements were given to 6 week old CBA mice beginning 3 days prior to inoculation with a murine sarcoma virus, the Moloney Sarcoma Virus (MSV). Although the basal diet contained 1.8% arginine and was therefore not arginine‐deficient, supplementation of the diet and the drinking water with 0.5% arginine HCl reduced tumor incidence, lengthened the latency period, decreased tumor size, and hastened tumor regression. Arginine also increased thymic weight and cellularity in normal and in MSV‐inoculated mice. The antitumor action of arginine may be related to its effect on the thymus.