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High Calorie Infusion‐induced Hepatic Impairments in Infants
Author(s) -
Hirai Yoshinori,
Sanada Yutaka,
Fujiwara Toshio,
Hasegawa Shiro,
Kuwabara Noriyuki
Publication year - 1979
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/014860717900300307
Subject(s) - alkaline phosphatase , calorie , medicine , transaminase , bilirubin , context (archaeology) , endocrinology , etiology , liver function tests , alanine transaminase , gastroenterology , aspartate transaminase , liver function , biology , biochemistry , enzyme , paleontology
Hepatic impairments have been reported sporadically in infants receiving long‐term high calorie infusion. Some characteristic hepatic impairments induced with high calorie infusion at the Juntendo University Hospital, Tokyo, are studied in 18 surgical infants, with discussion of the possible etiology of this complication in the context of high calorie infusion. The hepatic dysfunctions were classified into 3 types by sequential liver function determinations: Type I with a transient and slightly elevated serum transaminase without elevation of alkaline phosphatase; Type II, an elevation of alkaline phosphatase and total and direct bilirubin without elevation of serum transaminase; Type III, a marked and prolonged elevation of aklaline phosphatase, total and direct bilirubin, and serum transaminase. The etiology of these hepatic impairments during high calorie infusion is unknown.