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Specific Muscle Protein‐sparing Postoperative Dextrose‐free Amino Acid Infusions
Author(s) -
Kaminski M.V.,
Dunn N.P.,
Wannemacher R.W.,
Dinterman R.E.,
DeShazo R.,
Wilson W.W.,
Carlson D.E.
Publication year - 1977
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/014860717700100301
Subject(s) - nitrogen balance , acetone , amino acid , saline , excretion , muscle protein , protein catabolism , chemistry , urinary system , protein metabolism , medicine , anesthesia , endocrinology , biochemistry , nitrogen , skeletal muscle , organic chemistry
The protein‐sparing and ketogenic effect of postoperative infusion of maintenance solutions containing either 3.5% amino acids or 5% dextrose in 0.33 normal (N) saline was compared by nitrogen balance and urinary acetone determination in 31 patients. A specific muscle protein sparing effect was determined by quantitation of excretion of 3‐methylhistidine in seven patients of the amino acid group and eight patients in the dextrose group. In addition, an extensive hormone and substrate profile was determined. It was found that amino acid infusions not only produce a less negative nitrogen balance but also significantly reduce excretion of 3‐methylhistidine indicating specific preservation of the muscle compartment.