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Pharmaceutical and Clinical Aspects of Lipid Injectable Emulsions
Author(s) -
Driscoll David F.
Publication year - 2017
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607116673187
Subject(s) - emulsion , food science , lipid emulsion , soybean oil , chemistry , fatty acid , microbiology and biotechnology , parenteral nutrition , medicine , biochemistry , intensive care medicine , biology
The first clinically successful lipid injectable emulsion was marketed in 1961, consisting of soybean oil triglycerides in sterile water for injection. Since that time, numerous products have entered the market, with the main difference being changes in the oil composition with triglycerides of plant and marine oil origin. With this change, the fatty acid profiles are unique, coming from medium‐ and long‐chain triglycerides. The fatty acids can be saturated or unsaturated, having different pharmaceutical and metabolic activities that affect the safety and efficacy of these unique pharmaceutical dosage forms.