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Clinically Relevant Mechanisms of Lipid Synthesis, Transport, and Storage
Author(s) -
Kalish Brian T.,
Fell Gillian L.,
Nandivada Prathima,
Puder Mark
Publication year - 2015
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607115595974
Subject(s) - lipid metabolism , pathogenesis , lipid droplet , nonalcoholic fatty liver disease , disease , biology , computational biology , microbiology and biotechnology , chemistry , biochemistry , medicine , fatty liver , immunology , pathology
Lipids not only are fundamental nutrients but also serve as basic structural components of cells and as multifunctional signaling molecules. Lipid metabolism pathways underlie basic processes in health and disease and are the targets of novel therapeutics. In this review, we explore the molecular control of lipid synthesis, trafficking, and storage, with a focus on clinically relevant pathways. To illustrate the clinical relevance of molecular lipid regulation, we highlight how these biochemical processes contribute to the pathogenesis of nonalcoholic fatty liver disease, a component of the metabolic syndrome and a paradigmatic example of lipid dysregulation.