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Clinical Management of Patients With Parenteral Nutrition–Dependent Short Bowel Syndrome During Teduglutide Therapy
Author(s) -
Compher Charlene,
Boullata Joseph I.,
PickettBlakely Octavia,
Schiavone Phyllis,
Stoner Nancy,
Kinosian Bruce P.
Publication year - 2016
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607115594010
Subject(s) - medicine , parenteral nutrition , short bowel syndrome , intestinal failure , adverse effect , clinical trial , glucagon like peptide 2 , gastroenterology , intensive care medicine , peptide , biochemistry , chemistry
Background: Patients with intestinal failure, who are dependent on parenteral nutrition (PN) to supplement their limited absorption of dietary nutrients, are subject to complications associated with long‐term PN therapy. Medication therapy that results in improved dietary nutrient absorption may enable these patients to reduce or even become independent from PN therapy and its related complications. The glucagon‐like peptide 2 (GLP‐2) analogue teduglutide was approved for use in such patients by the U.S. Food and Drug Administration in 2012. Purpose : The purpose of this article is to describe the experience of 7 patients with PN‐dependent intestinal failure who were treated with teduglutide by a single center that had been involved in the teduglutide clinical trials. Results : Two patients who were treated during the clinical trials and 5 others who were treated since teduglutide came to market in the United States are described. Protocols used to prepare and monitor patients with this drug and PN weaning and adverse event outcomes are presented. Conclusions : While some patients had uncomplicated PN reduction, others experienced various complications. Careful monitoring of patients' clinical course is needed during drug therapy.