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Impact of Disease Activity on Resting Energy Expenditure and Body Composition in Adult Crohn's Disease
Author(s) -
Gong Jianfeng,
Zuo Lugen,
Guo Zhen,
Zhang Liang,
Li Yi,
Gu Lili,
Zhao Jie,
Cao Lei,
Zhu Weiming,
Li Ning,
Li Jieshou
Publication year - 2015
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607114528360
Subject(s) - bioelectrical impedance analysis , medicine , resting energy expenditure , body mass index , crohn's disease , calorie , disease , erythrocyte sedimentation rate , gastroenterology , mass index , physiology , body weight
Background : There is controversy about nutrition status and calorie needs during phases of active versus inactive adult Crohn's disease (CD). Results have been reported in cross‐sectional studies, but longitudinal data are unavailable. Our aim was to explore whether disease activity had an impact on resting energy expenditure (REE) and body composition in adult patients with CD. Materials and Methods : Adult patients were studied on 2 occasions with active and inactive CD. REE was measured by indirect calorimetry. Body composition was estimated from bioelectrical impedance analysis. Disease activity was measured using the Crohn's Disease Activity Index (CDAI). Regression analyses of REE with CDAI score, C‐reactive protein, and erythrocyte sedimentation rate were also performed. Results : Seventy‐five patients were included. Patients with active CD had increased REE/body weight compared with patients with inactive disease (28.8 ± 5.4 vs 25.9 ± 4.3 kcal/kg, P < .001). Disease behavior and location, but not sex, had an impact on REE/body weight. Body mass index was lower in active disease than in remission (17.4 ± 3.0 vs 18.1 ± 2.6 kg/m 2 , P = .010). Body composition was not affected by disease behavior or location. Conclusion : Patients with remission had a better nutrition status and decreased REE compared with those with active CD. REE could also be affected by disease location and behavior.