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Whey Peptide–Based Formulas With ω‐3 Fatty Acids Are Protective in Lipopolysaccharide‐Mediated Sepsis
Author(s) -
Tsutsumi Rie,
Horikawa Yousuke T.,
Kume Katsuyoshi,
Tanaka Katsuya,
Kasai Asuka,
Kadota Takako,
Tsutsumi Yasuo M.
Publication year - 2015
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607114520993
Subject(s) - lipopolysaccharide , sepsis , peptide , medicine , chemistry , pharmacology , biochemistry , immunology
Background: Sepsis and septic shock syndrome are among the leading causes of death in critically ill patients. Lipopolysaccharide (LPS) released by bacteria within the colon may translocate across a compromised epithelium, leading to oxidative stress, inflammation, sepsis, and eventually death. Methods : We examined the effects of a whey‐based enteral formula high in cysteine (antioxidant precursor) and the addition of ω‐3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), against a mouse model of LPS‐induced sepsis. Mice were fed either a whey‐based diet with EPA‐DHA (PAF), a whey‐based diet without EPA‐DHA (PSTD), or a casein‐based control diet (CONT). Results : Mice fed PAF or PSTD were protected against LPS‐induced weight loss. Whey‐based diets suppressed inflammatory cytokine release and oxidative stress damage. Furthermore, PAF and PSTD were able to inhibit autophagy, a mechanism in which the cell recycles damaged organelles. These anti‐inflammatory and antioxidative effects of PSTD and PAF resulted in decreased liver inflammation and intestinal damage and promoted protective microbiota within the intestines. Conclusions : These data suggest a clinical role for whey peptide–based diets in promoting healing and recovery in critically ill patients.