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Selenium Deficiency in Pediatric Patients With Intestinal Failure as a Consequence of Drug Shortage
Author(s) -
Davis Cheryl,
Javid Patrick J.,
Horslen Simon
Publication year - 2014
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607113486005
Subject(s) - medicine , economic shortage , selenium , medical prescription , parenteral nutrition , cohort , selenium deficiency , food shortage , food and drug administration , intensive care medicine , pediatrics , gastroenterology , environmental health , pharmacology , chemistry , ecology , linguistics , philosophy , catalase , oxidative stress , organic chemistry , glutathione peroxidase , government (linguistics) , biology
Background : Parenteral nutrition (PN) is a lifesaving therapy for children with intestinal failure and can now be used chronically without the life‐threatening complications of the past. Adequate intravenous trace element supplementation is required as part of a complete nutrition prescription. According to the U.S. Food and Drug Administration (FDA), the number of drug shortages, including sterile injectable agents used as PN components, has increased since 2010. Selenious acid as an individual additive was recently unavailable at our institution for 9 months due to a national shortage. Materials and Methods : To assess the impact of the selenious acid shortage, we retrospectively compiled data from existing clinical records for eligible patients. We included children with intestinal failure on full PN support who were older than 1 year at the onset of the selenium shortage. Whole‐blood selenium concentrations prior to the selenious acid shortage were compared with concentrations drawn during the shortage. Results : Five patients with intestinal failure and complete PN dependence were identified, and all 5 patients had normal serum selenium concentrations prior to the shortage. All 5 patients developed severe biochemical selenium deficiency in direct correlation with the shortage of selenium. No morbidity associated with selenium deficiency was observed. Selenium concentrations recovered after selenium supplementation was reinstituted. Conclusion : A national selenious acid shortage was associated with biochemical selenium deficiency in a cohort of children with intestinal failure. Despite very low selenium concentrations, none of our patients exhibited clinical signs of deficiency.