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A Rare Case of Hyperammonemia Complication of High‐Protein Parenteral Nutrition
Author(s) -
Pillai Unnikrishnan,
Kahlon Roopkiranjot,
Sondheimer James,
Cadnapaphorncai Pravit,
Bhat Zeenat
Publication year - 2013
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607112447815
Subject(s) - hyperammonemia , urea cycle , parenteral nutrition , medicine , complication , metabolic disorder , cerebral edema , pediatrics , gastroenterology , intensive care medicine , biochemistry , chemistry , amino acid , arginine
Hyperammonemia is a metabolic derangement that can be potentially fatal. Primary hyperammonemia due to urea cycle enzyme deficiency is usually discovered in neonates but rarely can present in adulthood. Late‐onset manifestations of urea cycle disorders can go unnoticed, until they become life threatening. The authors report a 28‐year‐old man who developed hyperammonemia in the hospital following parenteral nutrition (PN), leading to cerebral edema, which was fatal despite resolution of the hyperammonemia with cessation of PN and the use of continuous renal replacement therapy.