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Effects of Perioperative Synbiotic Treatment on Infectious Complications, Intestinal Integrity, and Fecal Flora and Organic Acids in Hepatic Surgery With or Without Cirrhosis
Author(s) -
Usami Makoto,
Miyoshi Makoto,
Kanbara Yoshihiro,
Aoyama Michiko,
Sakaki Hiroe,
Shuno Katsuhito,
Hirata Kenrou,
Takahashi Masanori,
Ueno Kimihiko,
Tabata Shouzou,
Asahara Takashi,
Nomoto Koji
Publication year - 2011
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607110379813
Subject(s) - synbiotics , gastroenterology , medicine , cirrhosis , perioperative , feces , probiotic , surgery , microbiology and biotechnology , biology , genetics , bacteria
Background : The aim of this study was to assess the effect of preoperative and postoperative synbiotic treatment in hepatectomy patients with or without liver cirrhosis. Methods : Sixty‐one patients with hepatic cancer were assigned randomly to receive either oral synbiotics that consisted of Bifidobacterium, Lactobacillus , and galactooligosaccharides or no synbiotics (control) preoperatively for 14 days and postoperatively for 11 days. Infectious complications, intestinal mucosal integrity as measured by serum diamine oxidase (DAO) activity, and fecal flora and organic acid concentrations were compared between synbiotic treatment (n = 32) and control (n = 29) groups. Results : Fecal flora culture and organic acid concentrations were changed after hepatectomy in both groups. The postsurgery decrease in DAO activity was less profound in the synbiotic‐treated group ( P < .01) and was correlated negatively with serum interleukin 6 and C‐reactive protein concentrations ( P < .001). Infectious complications occurred in 5 (17.2%) patients in the control group and no patients in the synbiotic‐treated group ( P < .05). Conclusion : Perioperative synbiotic treatment attenuated the decrease in intestinal integrity and reduced the rate of infectious complications in patients with or without liver cirrhosis who underwent hepatic surgery.