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Drug‐Induced Hyperphagia: What Can We Learn From Psychiatric Medications?
Author(s) -
Jensen Gordon L.
Publication year - 2008
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607108321708
Subject(s) - psychological intervention , drug , medicine , weight gain , dosing , appetite , adverse effect , psychiatry , etiology , intensive care medicine , intervention (counseling) , obesity , scope (computer science) , bioinformatics , pharmacology , body weight , biology , computer science , programming language
This brief review examines hyperphagia and associated weight gain as undesirable side effects of psychiatric medications; exploring the scope of the problem, proposed mechanisms, and potential interventions. Mechanisms of action appear to include drug‐mediated effects on hypothalamic appetite pathways that have been implicated in other etiologies of obesity. There is great individual variation in response to these medications as well as variation in the degree of weight gain within drug classes. Gene polymorphisms may be a key factor in determining individual variations in response. Better understanding of the underlying mechanisms can guide useful interventions. Medication selection and dosing appear to be important strategies to minimize adverse weight gain.