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Effect of Liquid Pancreatic Enzymes on the Assimilation of Fat in Different Liquid Formula Diets
Author(s) -
Hauenschild Annette,
Ewald Nils,
Klauke Thorsten,
Liebchen Ariane,
Bretzel Reinhard Georg,
Kloer HansUlrich,
Hardt Philip Daniel
Publication year - 2008
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/014860710803200198
Subject(s) - lipolysis , enteral administration , assimilation (phonology) , parenteral nutrition , exocrine pancreatic insufficiency , calorie , enzyme , medicine , endocrinology , pancreatic enzymes , liquid diet , pancreas , gastroenterology , food science , chemistry , biochemistry , adipose tissue , alcohol , linguistics , philosophy
Background: In some diseases, patients require high‐calorie tube feeding with standard enteral formulas usually administered via temporal feeding tubes. One frequent pathophysiological condition in a relevant number of these patients is exocrine pancreatic insufficiency. Patients unable to swallow capsules might benefit from a liquid pancreatic enzyme (LPE) preparation. Methods: LPEs were prepared and mixed with different commercially available formula diets produced for enteral feeding. Lipolysis was then measured by fatty acid titration. Results: Complete lipolysis by liquid enzyme preparations was observed in diverse formula diets. Fat assimilation was even complete when LPE had been prepared 3.5 hours before the experiments, showing that the enzymes had been stable up to that time. Conclusions: The use of LPEs seems to be a good therapeutic option in patients with exocrine pancreatic insufficiency and the need for permanent high‐calorie enteral feeding. Pharmaceutical companies should therefore be further encouraged to develop and distribute liquid enzyme preparations.