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Parenteral Nutrition as a Risk Factor for Central Venous Catheter–Related Infection
Author(s) -
Beghetto Mariur G.,
Victorino Josué,
Teixeira Luciana,
Azevedo Mirela J.
Publication year - 2005
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607105029005367
Subject(s) - medicine , central venous catheter , parenteral nutrition , odds ratio , risk factor , catheter , confidence interval , relative risk , surgery , gastroenterology , anesthesia
Background: The role of parenteral nutrition (PN) therapy as an independent risk factor for central venous catheter (CVC)–related infection in nonselected adult patients is not well established. The aim of this study was to evaluate PN as a risk factor for central venous catheter–related infection in nonselected adult patients in a general university hospital. Methods: Patients using central venous catheters, exposed or nonexposed to PN, were prospectively followed for development of central venous catheter–related infection. Results: One hundred fifty‐three patients were studied; 28 developed central venous catheter–related infection. Patients with central venous catheter–related infection presented higher frequency of PN use than patients without infection (60.7 vs 34.4%; p = .010). Multivariate Cox analysis showed that PN (relative risk (RR) = 3.30; 95% confidence interval [CI], 1.30–8.34; p = .012) was the only risk factor for central venous catheter–related infection. Malnutrition (RR = 0.45; 95% CI, 0.15–1.34; p = .152), days of hospitalization before central venous catheter insertion (RR = 1.00; 95% CI, 0.98–1.02; p = .801), and sustained hyperglycemia (RR = 0.49; 95% CI, 0.98–1.21; p = .091) were not significant in the model. Multiple logistic regression revealed that mal‐nutrition (odds ratio [OR] = 8.05; 95% CI, 1.85–35.03; p = .005), central venous catheter indication for surgical‐related pathology (OR = 7.26; 95% CI, 2.51–21.04; p < .001), sustained hyperglycemia (OR = 4.34; 95% CI, 1.79–10.52; p = .001), and days of hospitalization before central venous catheter insertion (OR = 1.04; 95% CI, 1.01–1.07; p = .004) were associated with PN use after adjustment for Assessment Score Intervention System score (OR = 0.33; 95% CI, 0.14–0.80; p = .014). Conclusions: PN therapy is an independent risk factor for central venous catheter–related infection in nonselected hospitalized adult patients.