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Clinical aspects of essential fatty acid metabolism: Jonathan Rhoads Lecture
Author(s) -
Bistrian BR
Publication year - 2003
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607103027003168
Subject(s) - docosahexaenoic acid , polyunsaturated fatty acid , eicosapentaenoic acid , arachidonic acid , cyp2c8 , essential fatty acid , metabolism , phospholipid , fatty acid , linoleic acid , fatty acid metabolism , biochemistry , chemistry , medicine , endocrinology , biology , physiology , membrane , cyp2c9 , enzyme , cytochrome p450
The clinical implications of the metabolism of the 2 essential fatty acids, linoleic and alpha‐linolenic acid, are most clearly related to the membrane phospholipid concentrations of their elongation and desaturation products, arachidonic, eicosapentaenoic, and docosahexaenoic acid. Levels of these very long chain polyunsaturated fatty acids can be altered by diet, prematurity, and disease which can affect growth (nutritional repletion) and the intensity and character of systemic inflammation as well as cognitive and visual function in infants.