z-logo
Premium
Kinetics of diethylhexyl‐phthalate extraction From polyvinylchloride‐infusion lines
Author(s) -
Loff S,
Kabs F,
Subotic U,
Schaible T,
Reinecke F,
Langbein M
Publication year - 2002
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607102026005305
Subject(s) - phthalate , extraction (chemistry) , kinetics , chromatography , chemistry , medicine , organic chemistry , physics , quantum mechanics
BACKGROUND: For infusion therapy, polyvinylchloride (PVC)‐infusion lines are commonly used. In this study, we examined the temperature dependency and the dynamics of extraction in the time course of infusion. METHODS: PVC‐infusion lines used on the newborn ICU were perfused with a typical 24‐hour fat infusion. We collected the perfused solution and measured the concentration of DEHP. This procedure was carried out at 27 degrees C and 33 degrees C. In another experiment, we examined the extraction rate in the time course of a 24‐hour infusion. The infusion was collected every 4 hours. RESULTS: We discovered that extraction of DEHP depends highly on the surrounding temperature. Whereas at 27 degrees C, the extraction of DEHP was 422.78 microg/mL, the leaching reached 540.78 microg/mL at 33 degrees C under otherwise identical conditions. This is important because the temperature on a newborn ICU is between 31 and 37 degrees C in an incubator. In the other experiment, we found out that the extraction rate rose from 25.44 microg/mL in the first 4 hours to 478.1 microg/mL after 24 hours. CONCLUSIONS: The result of this study is that the actual daily load of DEHP for a 2‐kg newborn is 30% higher than measured before. The rate of extraction is dependent on the time of contact between solution and tubing. If PVC‐infusion systems are used, solutions should be as cold as possible, and infusion time should be as short as possible.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here