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Lipid Peroxidation of Intravenous Lipid Emulsions and All‐in‐One Admixtures in Total Parenteral Nutrition Bags: The Influence of Trace Elements
Author(s) -
Steger Patrick J. K.,
Mühlebach Stefan F.
Publication year - 2000
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/014860710002400137
Subject(s) - iodometry , chemistry , lipid peroxidation , lipid emulsion , trace amounts , emulsion , lipid oxidation , peroxide , lipid peroxide , chromatography , biochemistry , antioxidant , parenteral nutrition , inorganic chemistry , medicine , organic chemistry , alternative medicine , pathology
An iodometric titration was used to assess the influence of a daily portion of trace elements on lipid peroxidation of pure lipid emulsions and lipid‐containing all‐in‐one (AIO) admixtures by measuring the peroxide value (PV; mmol peroxides/L). A pure lipid emulsion (Intralipid 20%; Pharmacia & Upjohn, Dübendorf, Switzerland) was stored in ethylvinylacetate bags under light protection (LP) at 40° C with and without trace elements. In absence of trace elements the PV of Intralipid 20% was significantly lower (day 14: 2.77 vs 18.04; p <.001). After the same time period with the same storage conditions the drop in pH was two times higher in presence of trace elements (1.54 vs 0.77). In an AIO admixture with LP stored at 2°C to 8°C, trace elements increased the PV from 0.04 to 0.19 mmol/L (day 29; p <.01). The drop in pH was 0.01 and 0.02 units, respectively. When stored at 20°C to 30°C and exposed to daylight, the PV of the AIO admixture containing trace elements reached 1.92 compared with 0.52 in their absence (day 19; p <.001) with a pH drop of 0.03 and 0.11, respectively (day 29). Although trace elements led to a much higher drop in pH in pure lipid emulsions, no obvious influence on the pH of AIO admixtures was demonstrated. To minimize lipid peroxidation, AIO admixtures should be stored light‐protected and refrigerated without trace elements. The latter should be added immediately before administration or should be given separately. (Journal of Parenteral and Enteral Nutrition 24: 37–41, 2000)