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Medication‐Nutrient Interactions: Hypophosphatemia Associated With Sucralfate in the Intensive Care Unit
Author(s) -
Miller Sarah Johnston,
Simpson Jeff
Publication year - 1991
Publication title -
nutrition in clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.725
H-Index - 71
eISSN - 1941-2452
pISSN - 0884-5336
DOI - 10.1177/0115426591006005199
Subject(s) - sucralfate , medicine , hypophosphatemia , intensive care unit , respiratory alkalosis , phosphorus , antacid , gastroenterology , intensive care medicine , materials science , metabolic acidosis , metallurgy
Clinically significant medication‐nutrient interactions are of concern to the nutritional support practitioner. To emphasize the possible effect of the aluminum‐containing medication sucralfate on serum phosphorus levels, patients admitted to the intensive care unit of a small private hospital were monitored for a 4‐week period. Sixteen patients demonstrated low serum phosphorus levels; eight (50%) of these were receiving sucralfate. Eighteen patients had no low phosphorus levels measured; five (28%) patients in this group were receiving sucralfate. The hypophosphatemia observed in these patients was probably multifactorial; respiratory alkalosis and dextrose feeding as well as sucralfate use are consistent with hypophosphatemia.