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A Review of the Relationship Between Parenteral Nutrition and Metabolic Bone Disease
Author(s) -
Ferrone Marcus,
Geraci Matthew
Publication year - 2007
Publication title -
nutrition in clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.725
H-Index - 71
eISSN - 1941-2452
pISSN - 0884-5336
DOI - 10.1177/0115426507022003329
Subject(s) - medicine , parenteral nutrition , metabolic bone disease , etiology , complication , intensive care medicine , disease , malnutrition , vitamin d and neurology , bone resorption , concomitant , bone disease , osteoporosis , surgery
Metabolic bone disease (MBD) refers to the conditions that produce a diffuse decrease in bone density and strength because of an imbalance between bone resorption and bone formation. MBD can be a potential complication in patients receiving chronic parenteral nutrition (PN) therapy and the management of this condition presents a challenge for many clinicians. The etiology of PN‐associated MBD is poorly understood, but traditional risk factors can include malnutrition, vitamin and mineral deficiencies, toxic contaminants in the PN solution, concomitant medications, and presence of certain disease states. Although additional studies are warranted to further elucidate the development and management of this condition, the following review discusses some of the important factors that may play a role in the genesis of PN‐associated MBD and evaluates some potential strategies for the diagnosis and treatment of this complication.