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Differential Effect of Weight Loss on Insulin Resistance in Surgically Treated Obese Patients
Author(s) -
Hughes Caren,
Ferrone Marcus
Publication year - 2006
Publication title -
nutrition in clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.725
H-Index - 71
eISSN - 1941-2452
pISSN - 0884-5336
DOI - 10.1177/011542650602100192
Subject(s) - medicine , insulin resistance , insulin , weight loss , biliopancreatic diversion , body mass index , obesity , endocrinology , gastroenterology , gastric bypass , surgery
Purpose: To compare the effects of equivalent weight loss induced by two bariatric surgical techniques on insulin action in severely obese patients. Methods: Eighteen nondiabetic patients with severe obesity (mean [± SD] body mass index: 53.5 ± 9 kg/m 2 ) and 20 sex‐ and age‐matched lean subjects (body mass index: 23.8 ± 3 kg/m 2 ) underwent metabolic studies, including measurement of insulin sensitivity by the insulin clamp technique. Patients then underwent either vertical banded gastroplasty with Roux‐en‐Y gastric bypass or biliopancreatic diversion and were restudied at 5–6 months and again at 16–24 months postsurgery. Results: At baseline, patients were hyperinsulinemic (194 ± 47 pmol/L vs 55 ± 25 pmol/L, p < .0001), hypertriglyceridemic (1.56 ± 0.30 mmol/L vs 0.78 ± 0.32 mmol/L, p < .0001), and profoundly insulin resistant (insulin‐mediated glucose disposal: 20.8 ± 4.4μ mol/min/kg fat‐free mass vs 52 ± 10.1 μmol/min/kg, p < .0001) as compared with controls. Weight loss by the 2 procedures was equivalent in both amount (averaging –53 kg) and time course. In the gastric bypass group, insulin sensitivity improved (23.8± 6 μmol/min/kg at 5 months and 33.7 ± 11.3 μmol/min/kg at 16 months, p < .01 vs baseline and controls). In contrast, in the biliopancreatic diversion group, insulin sensitivity was normalized already at 6 months (52.5 ± 12.4 μmol/min/kg, p = .72 vs controls) and increased further at 24 months (68.7 ± 9.5 μmol/min/kg, p < .01 vs controls), despite a persistent obese phenotype (body mass index 33.2 ± 8 kg/m 2 ). Conclusions: In surgically treated obese patients, insulin sensitivity improves in proportion to weight loss with use of predominantly restrictive procedures (gastric bypass) but is reversed completely by predominantly malabsorptive approaches (biliopancreatic diversion) long before normalization of body weight. Selective nutrient absorption and gut hormones may interact with one another in the genesis of the metabolic abnormalities of obesity.