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Multicentre, Cluster‐Randomized Clinical Trial of Algorithms for Critical‐Care Enteral and Parenteral Therapy (ACCEPT).
Author(s) -
Martin CM,
Doig GS,
Heyland DK,
Morrison T,
Sibbald WJ
Publication year - 2004
Publication title -
nutrition in clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.725
H-Index - 71
eISSN - 1941-2452
pISSN - 0884-5336
DOI - 10.1177/0115426504019003309
Subject(s) - medicine , parenteral nutrition , randomized controlled trial , intensive care , enteral administration , intervention (counseling) , intensive care unit , cluster (spacecraft) , emergency medicine , intensive care medicine , pediatrics , nursing , computer science , programming language
Background: The provision of nutrition support for patients in intensive care units (ICUs) varies widely both within and between institutions. We tested the hypothesis that evidence‐based algorithms to improve nutrition support in the ICU would improve patient outcomes. Methods: A cluster‐randomized controlled trial was performed in the ICUs of 11 community and 3 teaching hospitals between October 1997 and September 1998. Hospital ICUs were stratified by hospital type and randomized to the intervention or control arm. Patients at least 16 years of age with an expected ICU stay of at least 48 hours were enrolled in the study ( n = 499). Evidence‐based recommendations were introduced in the 7 intervention hospitals by means of in‐service education sessions, reminders (local dietitian, posters) and academic detailing that stressed early institution of nutrition support, preferably enteral. Results: Two hospitals crossed over and were excluded from the primary analysis. Compared with the patients in the control hospitals ( n = 214), the patients in the intervention hospitals ( n = 248) received significantly more days of enteral nutrition (6.7 vs 5.4 per 10 patient‐days; p = .042), had a significantly shorter mean stay in hospital (25 vs 35 days; p = .003) and showed a trend toward reduced mortality (27% vs 37%; p = .058). The mean stay in the ICU did not differ between the control and intervention groups (10.9 vs 11.8 days; p = .7). Interpretation: Implementation of evidence‐based recommendations improved the provision of nutrition support and was associated with improved clinical outcomes.