Mechanisms and Treatment of Postoperative Ileus

To review the pathogenesis and treatment of postoperative ileus, articles were identified from a MEDLINE database search of the English language literature. The exact indexing terms were “postoperative ileus,”“ treatment,” “etiology,” and“ pathophysiology.” Previous review articles and pertinent references from those articles were also used. All relevant studies were included. Only articles that were case presentations or that mentioned postoperative ileus in passing were excluded. The pathogenesis of postoperative ileus is complex, with multiple factors contributing either simultaneously or at various times during the development of this entity. These factors include inhibitory effects of sympathetic input; release of hormones, neurotransmitters, and other mediators; an inflammatory reaction; and the effects of anesthetics and analgesics. Numerous treatments have been used to alleviate postoperative ileus without much success. The etiology of postoperative ileus can best be described as multifactorial. A multimodality treatment approach should include limiting the administration of agents known to contribute to postoperative ileus (narcotics), using thoracic epidurals with local anesthetics when possible, and selectively applying nasogastric decompression.