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Nutritional Approach in Malnourished Surgical Patients: A Prospective Randomized Study
Author(s) -
Braga M,
Gianotti L,
Nespoli L,
Radaelli G,
Di Carlo V
Publication year - 2002
Publication title -
nutrition in clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.725
H-Index - 71
eISSN - 1941-2452
pISSN - 0884-5336
DOI - 10.1177/0115426502017005325
Subject(s) - medicine , perioperative , enteral administration , randomization , randomized controlled trial , surgery , parenteral nutrition , prospective cohort study , demographics , elective surgery , anesthesia , demography , sociology
Hypothesis: Perioperative administration of a supplemented enteral formula may decrease postoperative morbidity. Design: Randomized clinical trial. Setting: Department of surgery at a university hospital. Patients: One hundred ninety‐six registered malnourished patients (weight loss > or = 10%) who were candidates for major elective surgery for malignancy of the gastrointestinal tract. Intervention: After randomization (n = 150), one group received postoperative enteral feeding with a standard diet within 12 hours of surgery (control group; n = 50). Another group orally received 1 L/d for 7 consecutive days of a liquid diet enriched with arginine, omega‐3 fatty acids, and RNA (preoperative group; n = 50). After surgery, patients were given the same standard enteral formula as the control group. A third group orally received 1 L/d for 7 consecutive days of the enriched liquid diet. After surgery, patients were given enteral feeding with the same enriched formula (perioperative group; n = 50). Main Outcome Measures: Postoperative complications and length of hospital stay. Results: The 3 groups were comparable for baseline demographics, biochemical markers, comorbidity factors, and surgical variables. The intent‐to‐treat analysis showed that the total number of patients with complications was 24 in the control group, 14 in the preoperative group, and 9 in the perioperative group ( p = .02, control group versus perioperative group). Postoperative length of stay was significantly shorter in the preoperative (13.2 days) and perioperative (12.0 days) groups than in the control group (15.3 days) ( p = .01 and p = .001, respectively, versus the control group). Conclusion: Perioperative immunonutrition seems to be the best approach to support malnourished patients with cancer.