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Pharmacokinetic Changes of Theophylline and Amikacin through the Menstrual Cycle in Healthy Women
Author(s) -
Matsuki Shunji,
Kotegawa Tsutomu,
Tsutsumi Kimiko,
Nakamura Koichi,
Nakano Shigeyuki
Publication year - 1999
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/00912709922012060
Subject(s) - pharmacokinetics , amikacin , theophylline , luteal phase , medicine , menstrual cycle , follicular phase , pharmacology , chemistry , antibiotics , hormone , biochemistry
The objective of this open‐label, single‐dose study was to clarify the influence of the menstrual cycle on the pharmacokinetics of theophylline ( n = 10) and amikacin ( n = 8) in young healthy Japanese women with regular menstrual cycles. Each subject received an intravenous infusion of theophylline or amikacin sulfate at four different phases—mid‐follicular (phase I), periovulatory (phase II), mid‐luteal (phase III), and premenstrual days (phase IV). In the theophylline study, there were no significant differences in the pharmacokinetic parameters among the four phases studied. In the amikacin study, CL tot was 15% higher in phase III than in phase I ( p < 0.01). V dβ was 35% higher in phase III than in phase I ( p < 0.05). The other pharmacokinetic parameters of amikacin were not significantly altered during the menstrual cycle. Evidence suggests that the phase of the menstrual cycle maybe a factor in determining the pharmacokinetics of amikacin .