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Severe Life‐Threatening Hyponatremia during Paroxetine Therapy
Author(s) -
Odeh Majed,
Seligmann Hanna,
Oliven Arie
Publication year - 1999
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/00912709922011980
Subject(s) - hyponatremia , paroxetine , fluoxetine , medicine , complication , reuptake inhibitor , antidepressant , tricyclic antidepressant , delirium , fluvoxamine , intensive care medicine , anesthesia , serotonin , receptor , hippocampus
Hyponatremia secondary to the syndrome of inappropriate secretion of antiduretic hormone (SIADH) is an uncommon complication of treatment with the antidepressants the selective serotonin reuptake inhibitors (SSRIs). These effective antidepressant agents are becoming widely used because of their favorable side effect profile and their safety in overdose. Although most reports have implicated fluoxetine in causing hyponatremia, there have also been a few reports of hyponatremia associated with paroxetine. We describe an elderly patient with severe life‐threatening hyponatremia in association with paroxetine therapy The present case and the others previously reported emphasize the need for greater awareness of the development of this serious and potentially fatal complication, and suggest that serum sodium concentration should be measured periodically in elderly patients soon after they start taking any agent of the SSRIs, especially during the first 2 to 4 weeks of treatment.