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Disposition of Recombinant Human Interleukin‐10 in Subjects with Various Degrees of Renal Function
Author(s) -
Andersen Scott R.,
Lambrecht Lawrence J.,
Swan Suzanne K.,
Cutler David L.,
Radwanski Elaine,
Affrime Melton B.,
Garaud JeanJacques
Publication year - 1999
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/00912709922011773
Subject(s) - pharmacokinetics , volume of distribution , medicine , renal function , disposition , creatinine , bolus (digestion) , pharmacology , recombinant dna , urology , chemistry , psychology , social psychology , biochemistry , gene
The pharmacokinetics of intravenously administered recombinant human interleukin‐10 (rHuIL‐10) were evaluated in 18 subjects with creatinine clearances (Clcr) between 2.7 and 116.7 mL/min/1.73m 2 . Serum samples for rHuIL‐10 were obtained over a 48‐hour period after a single 25 μg/kg IV bolus infusion. AUC, total body clearance (Clp), and steady‐state volume of distribution (Vdss) were derived by compartmental methods. Analysis of serum concentrations showed statistically significant group differences for log‐transformed AUC and original scale Clp ( p < 0.01). The AUC and effective half‐life increased, while the mean Clp of rHuIL‐10 decreased as renal function declined. A linear relationship between AUC and Clcr as well as Clp and Clcr demonstrates that the disposition of rHuIL‐10 is altered in subjects with renal insufficiency. No serious adverse events were noted .