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Gabapentin Does Not Affect Antipyrine Clearance
Author(s) -
Allen Elizabeth,
Tsanaclis Lolita M.,
Wroe Steven J.,
Reece Phillip A.,
Sedman Allen J.
Publication year - 1999
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/00912709922008551
Subject(s) - gabapentin , phenytoin , anticonvulsant , pharmacology , medicine , drug interaction , pharmacokinetics , drug , anesthesia , epilepsy , alternative medicine , pathology , psychiatry
The effect of gabapentin on antipyrine clearance was assessed in 12 healthy male volunteers, using a known enzyme inducer, phenytoin, as control. Subjects received gabapentin 400 mg or phenytoin 100 mg three times daily for 2 weeks. Antipyrine tests were performed before, during, and after treatment with gabapentin or phenytoin. In contrast to phenytoin, chronic administration of gabapentin did not affect antipyrine clearance. Gabapentin appears to have little potential for drug interactions.