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Lack of Pharmacokinetic and Pharmacodynamic Interaction between Rizatriptan and Paroxetine
Author(s) -
Goldberg Michael R.,
Lowry Richard C.,
Musson Donald G.,
Birk Kimberly L.,
Fisher Allison,
DePuy M. Elizabeth,
Shadle Craig R.
Publication year - 1999
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/00912709922007633
Subject(s) - rizatriptan , paroxetine , crossover study , pharmacology , placebo , pharmacokinetics , medicine , anesthesia , sumatriptan , antidepressant , agonist , receptor , alternative medicine , pathology , hippocampus
Rizatriptan is a potent, oral 5‐HT 1B/1D agonist with a rapid onset of action being investigated for the acute treatment of migraine. This study examined the clinical and pharmacokinetic interaction between rizatriptan and the selective serotonin reuptake inhibitor, paroxetine. In this two‐period crossover study, 12 healthy young subjects (6 males and 6 females) received 10 mg rizatriptan following 14 days of treatment with placebo or paroxetine (20 mg once daily). Plasma was sampled for rizatriptan and N‐monodesmethyl rizatriptan, a minor but active metabolite of rizatriptan. Safety evaluations included monitoring for adverse events, vital signs, and visual analog scale assessment of mood. Plasma levels of rizatriptan and N‐monodesmethyl rizatriptan were not altered when rizatriptan was administered with paroxetine compared to the placebo. Clinically, coadministration of rizatriptan with paroxetine was well tolerated. Blood pressure, heart rate, and temperature changes during the observation period did not differ to a clinically significant degree when rizatriptan was administered with paroxetine compared to the placebo. No effects on mood occurred following treatment with the combination compared to rizatriptan alone. Adverse events following rizatriptan administration with paroxetine were similar to those reported when rizatriptan was given with the placebo.