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Pharmacokinetics and Pharmacodynamics of Famotidine in Infants
Author(s) -
James Laura P.,
Marotti Tonya,
Stowe Cindy D.,
Farrar Henry C.,
Taylor Bonnie J.,
Kearns Gregory L.
Publication year - 1998
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/009127009803801202
Subject(s) - famotidine , pharmacokinetics , volume of distribution , cmax , pharmacodynamics , medicine , urine , anesthesia , pharmacology
The pharmacokinetics and pharmacodynamics of intravenous famotidine were evaluated in 10 infants ranging from 5 to 19 days of age who had a therapeutic indication for the prophylactic treatment of stress ulceration. After a 0.5‐mg/kg infusion of famotidine, timed serum (n = 6), urine (24‐hour collection), and repeated measurements of gastric pH were obtained. The mean ± standard deviation maximum plasma concentration (C max ) was 640.66 ± 250.66 ng/mL, the elimination half‐life (t 1/2β ) was 10.51 ± 5.43 hours, and the apparent volume of distribution at steady state (Vd ss ) was 0.82 ± 0.29 L/kg. Plasma clearance (Cl) and renal clearance (Cl R ) were 0.132 ± 0.061 L/hr/kg and 0.093 ± 0.056 L/hr/kg, respectively. No significant correlations were found between t 1/2β , Vd ss , Cl, and Cl R and age. Six of the nine infants who had intragastric pH monitoring maintained a gastric pH > 4 until the final 24‐hour sampling point. In this study, the t 1/2β of famotidine was prolonged and the Vd ss , Cl, Cl R were reduced compared with corresponding parameters in previously reported studies of children older than one year of age and adults .