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Methods for Assessing the Effects of Drugs on Gastrointestinal Function in Patients and Healthy Volunteers
Author(s) -
Smith Jeffrey T. L.
Publication year - 1997
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/009127009703700119
Subject(s) - gastrointestinal tract , gastrointestinal function , medicine , clinical pharmacology , function (biology) , motility , intensive care medicine , pharmacology , biology , genetics , evolutionary biology
The gastrointestinal tract is a complex organ with many functions. Many diseases affect the way in which the gastrointestinal tract performs these functions. The pharmaceutical industry and academia are putting great effort into the development of treatments for these diseases. As a consequence, there is increasing pressure on the clinical pharmacologist and gastroenterologist to develop methods to measure the effects of drugs on the gastrointestinal tract. This article reviews the methods currently available to assess gastrointestinal function; in particular it focuses on motility and sensitivity.