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Temporal Variation in the Effects of Ophthalmic Timolol on Cardiovascular and Respiratory Functions in Healthy Men
Author(s) -
Umetsuki Megumi Hara,
Kotegawa Tsutomu,
Nakamura Koichi,
Nakano Shigeyuki,
Nakatsuka Kazuo
Publication year - 1997
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/009127009703700110
Subject(s) - timolol , medicine , respiratory system , anesthesia , cardiology , variation (astronomy) , ophthalmology , glaucoma , physics , astrophysics
This study examined the effects of ophthalmic timolol and time of administration on cardiovascular and respiratory functions in healthy young male volunteers. Eight participants (mean age ± standard deviation, 22 ± 0.9 years) received either 50 μL of 0.5% timolol or placebo in the lower conjunctival sacs of both eyes in the morning or evening. Intraocular pressure, blood pressure, heart rate, and respiratory functions, including percent forced expiratory volume in 1 second and peak expiratory flow rate, were then measured for 3 hours after drug administration. Timolol reduced intraocular pressure and cardiovascular function at both administration times. However, a timolol‐induced reduction in respiratory function was observed only in the evening: percent forced expiratory volume in 1 second, peak expiratory flow rate, and expiratory flow rate at 75% vital capacity were reduced by 3%, 7%, and 12%, respectively, 3 hours after administration. These results indicate that ophthalmic timolol reduces cardiovascular and respiratory functions in healthy young male subjects and that bronchial sensitivity to timolol differs between morning and evening.