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Controlled‐Release Formulations of Propranolol and Verapamil
Author(s) -
Dunn James
Publication year - 1987
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/009127008702700104
Subject(s) - verapamil , propranolol , pharmacology , dosage form , medicine , population , chemistry , calcium , environmental health
The in vitro and clinical behavior of new controlled‐release formulations of propranolol and verapamil are reviewed. In vitro dissolution studies have proved to be of little value in determining the clinical activity of these new dosage forms. There is a difference between the blood levels found with the new formulations and those of the reference products. The once‐daily verapamil product was evaluated in black hypertensive patients with promising results and suggests that this dosage form of verapamil may be successful as monotherapy for treating this patient population.