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Trimethobenzamide HCI in the Treatment of Nausea and Vomiting Associated with Antineoplastic Chemotherapy
Author(s) -
HURLEY JOHN D.,
ESHELMAN FRED N.
Publication year - 1980
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/009127008002000508
Subject(s) - nausea , vomiting , placebo , medicine , chemotherapy , anesthesia , incidence (geometry) , alternative medicine , physics , pathology , optics
Fifty-five patients undergoing chemotherapy for various neoplastic processes were treated with trimethobenzamide or placebo to control nausea and vomiting. Trimethobenzamide was shown to be significantly better than placebo in relieving periodic and total nausea over the 48-hour study. Vomiting incidence was also reduced in the group receiving trimethobenzamide. Differences were noted in the degree of emetic stimulus associated with different chemotherapeutic regimens. No side effects attributable to trimethobenzamide were recorded.