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Transient Hypotensive Effect of Phenytoin in Man
Author(s) -
SULLIVAN JAY M.,
SOLOMON HAROLD S.
Publication year - 1977
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/009127007701701008
Subject(s) - phenytoin , medicine , blood pressure , anesthesia , supine position , placebo , nifedipine , essential hypertension , epilepsy , alternative medicine , pathology , psychiatry , calcium
Phenytoin or an identically appearing placebo was administered in a double-blind fashion to 20 patients with mild essential hypertension. A significant fall in supine systolic blood pressure was noted 30 minutes to 1 hour after the oral administration of 100 mg phenytoin. No significant antihypertensive effect was observed after the patients had received 100 mg phenytoin every 8 hours for two weeks. Phenytoin had no effect on the diastolic blood pressure. It is concluded that the previously described hypotensive effect of phenytoin is a transient phenomenon which is of no therapeutic benefit in the long-term management of patients with essential hypertension.