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The Effects of Concomitant Administration of Theophylline and Toborinone on the Pharmacokinetics of Both Compounds in Poor and Extensive Metabolizers via CYP2D6
Author(s) -
Tammara Brinda,
Trang John M.,
Miyamoto Gohachiro,
Kitani Mami,
Brisson Jerry,
Bramer Steven L.
Publication year - 2002
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/00912700222011544
Subject(s) - theophylline , pharmacokinetics , pharmacology , concomitant , urine , oral administration , cyp2d6 , drug interaction , therapeutic index , medicine , chemistry , drug , cytochrome p450 , metabolism
This study investigated the effects of the concomitant administration of theophylline and toborinone on the pharmacokinetics of both compounds in poor and extensive metabolizers via CYP2D6. In period 1, a single dose of 3.5 mg/kg theophylline was administered orally. In period 2, a single dose of 1.0 μg/kg/min toborinone was infused over 6 hours. In period 3, 3.5 mg/kg theophylline was coadministered with 1.0 μg/kg/min toborinone. Serial blood and pooled urine samples were collected before and after toborinone administration for the quantification of toborinone and its metabolites in plasma and urine. Serial blood samples were collected before and after theophylline administration for the quantification of theophylline and its metabolites in plasma. No significant differences were observed in toborinone pharmacokinetics between poor and extensive metabolizers via CYP2D6. Toborinone coadministration with theophylline did not result in a substantive effect on the disposition of theophylline and vice versa.