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Low Molecular Weight Heparin‐Induced Liver Toxicity
Author(s) -
Hui CheeKin,
Yuen ManFung,
Ng Irene OiLin,
Tsang Kenneth WahTak,
Fong Gardian ChungYan,
Lai ChingLung
Publication year - 2001
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/00912700122010465
Subject(s) - heparin , low molecular weight heparin , medicine , liver biopsy , liver function tests , toxicity , liver function , gastroenterology , pulmonary embolism , liver injury , pathology , biopsy
The authors report two cases of hepatotoxicity induced by low molecular weight heparin. A 26‐year‐old woman and a 33‐year‐old man were treated with low molecular weight heparin for pulmonary embolism and cerebral infarction, respectively. They both developed derangement in liver function tests a few days after commencement of the low molecular weight heparin. The derangement in liver function tests was associated with a decreased serum complement 3 activity. Their liver functions recovered over a period of 2 to 3 months after low molecular weight heparin was stopped. Liver biopsy in the woman demonstrated balloon degeneration with scattered foci of hepatocytic necrosis, suggesting a complementmediated hepatocellular damage.