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Lack of Citalopram Effect on Oral Digoxin Pharmacokinetics
Author(s) -
Larsen Frank,
Priskorn Morten,
Overø Kerstin Fredricson
Publication year - 2001
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/00912700122010041
Subject(s) - digoxin , pharmacokinetics , cmax , medicine , citalopram , crossover study , urine , oral administration , pharmacology , drug interaction , concomitant , anesthesia , heart failure , placebo , antidepressant , alternative medicine , pathology , hippocampus
The effect of chronic administration of citalopram on the single oral dose pharmacokinetics of digoxin was evaluated in 11 healthy adult subjects in an open, one‐way crossover study. Subjects received 1 mg digoxin on day 1. Serial blood samples and total urine were collected over 192 hours, followed by an 11‐day washout period. On days 22 through 50, subjects received 40 mg citalopram once daily. On day 43, a single dose of1 mg digoxin was coadministered; again, serial blood samples and total urine were collected over 192 hours after the digoxin dose. There were no statistically significant differences in any of the digoxin pharmacokinetic parameters (AUC→,∞’ AUC→ C max’ t max’ t 1/2’ CL/F CL/ renal’ and Ae →∞ , and the 90% confidence intervals for treatment differences for the parameters (except for t max ) were all within 80% to 125%. Concomitant digoxin administration did not significantly affect citalopram pharmacokinetics. The treatment was well tolerated by all subjects; no serious adverse events and no clinically significant ECG changes were observed. These data suggest that it is unlikely that concomitantly administered citalopram would have any significant effect on serum digoxin concentrations in patients who are receiving chronic digoxin therapy.