Premium
Race but Not Age Affects Erythromycin Breath Test Results in Older Hypertensive Men
Author(s) -
Schwartz Janice B.
Publication year - 2001
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/00912700122010023
Subject(s) - medicine , dosing , erythromycin , cyp3a , african american , gastroenterology , antibiotics , metabolism , history , ethnology , cytochrome p450 , microbiology and biotechnology , biology
Erythromycin breath tests (ERBT) were performed to determine age and racial effects on CYP3A4‐mediated hepatic clearance in hypertensive men (n = 43) in the clinical setting. Older hypertensive African American men (n = 19: 71 ± 8 years, mean ± SD) had faster ERBT clearance compared with Caucasian (n = 20:72 ± 6 years) hypertensive men (at 20 minutes after dosing: 0.042 ± 0.01 percent dose/min exhaled vs. 0.033 ± 0.013; at 60 minutes after dosing: 0.030 ± 0.05 vs. 0.023 ± 0.007percent dose/min exhaled; ANOVA , p = 0.007), while age, smoking, and reported alcohol intake did not affect ERBT. The data suggest faster hepatic CYP3A‐mediated clearance in African American men compared with Caucasian men, and that race may significantly affect CYP3A‐mediated hepatic clearance in patients treated for hypertension .