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Lack of Interaction between Levofloxacin and Oxycodone: Pharmacokinetics and Drug Disposition
Author(s) -
Grant Edward M.,
Zhong Ming Kang,
Fitzgerald James F.,
Nicolau David P.,
Nightingale Charles,
Quintiliani Richard
Publication year - 2001
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/00912700122009890
Subject(s) - levofloxacin , cmax , oxycodone , pharmacokinetics , pharmacology , medicine , bioavailability , crossover study , trovafloxacin , ciprofloxacin , moxifloxacin , morphine , drug interaction , antibacterial agent , anesthesia , chemistry , antibiotics , opioid , placebo , receptor , alternative medicine , pathology , biochemistry
Previous studies have demonstrated a significant reduction in the oral bioavailability of trovafloxacin and ciprofloxacin when administered concomitantly with an intravenous opiate such as morphine. This decrease in absorption results in a 36% and 50% lower AUC for trovafloxacin and ciprofloxacin, respectively, which could cause clinical failures. The authors investigated the possibility of a similar interaction between oxycodone and levofloxacin. Eight healthy volunteers were randomized in an open‐label, two‐way crossover study to receive oxycodone, 5 mg po Q4H, and levofloxacin, 500 mg po 1 hour after starting the oxycodone or levofloxacin 500 mg po alone. Blood samples were drawn at 0, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, 18, and 24 hours for C max , t max , and AUC determinations. There was not a significant difference (p < 0.05) in AUC (48.59 ± 8.52 vs. 49.9 ± 9.93), C max (7.73 ± 2.6 vs. 6.6 ± 2.0), and t max (1.1 ± 0.6 vs. 1.6 ± 1.1) for levofloxacin versus levofloxacin/oxycodone regimens. It was concluded that oral oxycodone and levofloxacin can be administered concomitantly without a significant decrease in AUC, C max , or t max .