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The Effects of N‐Acetylcysteine and Deferoxamine on Plasma Cytokine and Oxidative Damage Parameters in Critically Ill Patients With Prolonged Hypotension: A Randomized Controlled Trial
Author(s) -
Fraga Cassiana Mazon,
Tomasi Cristiane Damiani,
Biff Daiane,
Topanotti Maria Fernanda Locks,
Felisberto Francine,
Vuolo Francieli,
Petronilho Fabricia,
DalPizzol Felipe,
Ritter Cristiane
Publication year - 2012
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/0091270011418657
Subject(s) - medicine , creatinine , placebo , deferoxamine , acute kidney injury , acetylcysteine , renal function , randomized controlled trial , gastroenterology , anesthesia , intensive care unit , pathology , chemistry , biochemistry , alternative medicine , antioxidant
Reactive oxygen species and inflammation have been implicated in renal tubule cell injury. However, there is some controversy concerning whether antioxidants might attenuate oxidative damage and inflammation in humans after hypotension in the setting of critical illness. This study was a prospective, randomized, double‐blinded, placebo‐controlled study that included patients with hypotension. Patients were randomized to receive either N‐acetylcysteine (NAC; 50 mg/kg by 4 hours followed by 100 mg/kg/d for 48 hours diluted in 5% glucose) and deferoxamine (DFX; at a single dose of 1000 mg diluted in 5% glucose) or placebo. The primary study outcome was the serum levels of markers of oxidative damage and inflammatory response. Secondary outcomes included the incidence of acute renal failure, serum creatinine at hospital discharge, intensive care unit length of stay, and length of hospital stay. Thirty patients were enrolled in the study. The use of NAC plus DFX decreased the oxidative damage parameters but not plasma interleukin‐6 levels. In contrast, plasma nitrite levels increased 24 hours after NAC plus DFX administration. On analysis of secondary outcomes, it was observed that creatinine levels at hospital discharge were lower in patients receiving NAC plus DFX when compared with placebo. NAC plus DFX administration was able to decrease plasma markers of oxidative damage and creatinine levels at hospital discharge.