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Pharmacokinetics of Oral Tonapofylline and Its Acyl‐Glucuronide Metabolite in Patients With Mild and Moderate Hepatic Impairment
Author(s) -
Li Zhaoyang,
Gan LiangShang,
Marbury Thomas,
Lasseter Kenneth C.,
Natarajan Amy,
Stecher Scott,
Wei Dong,
Yang Liyu,
Freedman Daniel,
Deykin Aaron
Publication year - 2012
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/0091270011400413
Subject(s) - pharmacokinetics , metabolite , capsule , medicine , oral administration , volume of distribution , area under the curve , geometric mean , glucuronidation , gastroenterology , chemistry , endocrinology , biology , in vitro , biochemistry , microsome , statistics , botany , mathematics
The objective of the study was to evaluate the effect of hepatic impairment on the pharmacokinetics of tonapofylline. Patients with mild or moderate hepatic impairment were enrolled in parallel with demographically matched healthy subjects. All study participants received a single 75‐mg oral tonapofylline capsule. The pharmacokinetic parameters for both tonapofylline and its active metabolite, acyl‐glucuronide (tonapofylline‐AG), were affected by hepatic impairment significantly ( P < .1) except for time to peak plasma concentration (t max ), terminal half‐life (t 1/2 ), and apparent volume of distribution based on the terminal phase (Vdz/F). In the mild group, peak plasma concentration (C max ), area under the time‐concentration curve from time 0 to 48 hours postdose (AUC 48h ), and from time 0 to infinity (AU Cinf ) of tonapofylline modestly increased as compared with the control healthy subjects (GMR 1.62, 1.57, and 1.53, respectively). The extent of increase of these parameters for tonapofylline‐AG was more profound than tonapofylline with geometric mean ratio (GMR) ranging from 2.02 to 2.08. Moderate hepatic impairment was also associated with modest increases of C max , AUC 48h , and AUC inf of tonapofylline (GMR 1.41, 1.98, and 2.08, respectively). Similar to the mild group, the increase of these parameters were higher for tonapofylline‐AG with GMR ranging from 2.80 to 3.86. Single oral 75‐mg tonapofylline was safe and well tolerated in patients with mild or moderate hepatic impairment.