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Effect of Microgravity on the Pharmacokinetics of Ibuprofen in Humans
Author(s) -
Idkaidek Nasir,
Arafat Tawfiq
Publication year - 2011
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/0091270010388652
Subject(s) - pharmacokinetics , ibuprofen , bioavailability , saliva , washout , absorption (acoustics) , pharmacology , chemistry , half life , absorption rate , medicine , chromatography , biochemistry , physics , acoustics
The pharmacokinetics of ibuprofen were studied under microgravity (μG) conditions and compared with those at normal gravity (1G) in humans. Six healthy human volunteers were given 600 mg oral dose ibuprofen during 1‐day simulated μG antiorthostatic bed rest position, then at normal position (1G) in a sequential design with 7 days washout time. Saliva and plasma samples were obtained up to 8 hours after dosing. Ibuprofen was not detected in all saliva samples. Pharmacokinetic parameters in plasma were calculated by either noncompartmental analysis or a 1‐compartment model using the Kinetica program. Absorption kinetic parameters were then predicted by ADAM and PE modules using the Simcyp program. Results have showed an increased rate of ibuprofen dissolution and absorption and hence faster onset of action under μG conditions. However, rate of drug elimination and bioavailability was not affected by μG, suggesting no need for dose adjustment.