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Daily Honey Consumption Does Not Change CYP3A Activity in Humans
Author(s) -
Fetzner Leonie,
Burhenne Jürgen,
Weiss Johanna,
Völker Michael,
Unger Matthias,
Mikus Gerd,
Haefeli Walter Emil
Publication year - 2011
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/0091270010382022
Subject(s) - cyp3a , midazolam , oral administration , medicine , volunteer , pharmacology , metabolism , biology , cytochrome p450 , sedation , agronomy
Several studies investigating the interaction of honey and drug‐metabolizing enzymes showed controversial results, with some suggesting that honey induces CYP3A‐mediated metabolism in mammals and humans. This clinical trial was conducted to determine the effect of repeated honey administration on human CYP3A enzyme activity using midazolam as a marker substance. In a randomized, single‐blind, parallel‐group study, 20 healthy volunteers were randomly assigned to receive either honey (2 × 20 g/d) or artificial honey (2 × 20 g/d) over a period of 10 days. To determine intestinal and hepatic CYP3A activity, oral (4 mg) and intravenous (2 mg) midazolam was administered in a semi‐simultaneous way before honey administration, after the last honey administration, and 1 and 6 days thereafter. At baseline after oral midazolam, the partial metabolic clearance was similar in both groups (honey: 917.8 ± 234.6 mL/min vs artificial honey: 973.5 ± 373.8 mL/min). Ten days of honey administration did not change partial metabolic clearance (honey: 1016 ± 268 mL/min vs artificial honey: 1043 ± 450 mL/min), which was also true 1 and 6 days later. Neither honey nor artificial honey in amounts usually consumed affected the intestinal and hepatic CYP3A activity in healthy volunteers.