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Synergy Between Scientific Advancement and Technological Innovation, Illustrated by a Mechanism‐Based Model Characterizing Sodium‐Glucose Cotransporter‐2 Inhibition
Author(s) -
Zhang Liping,
Ng Chee M.,
List James F.,
Pfister Marc
Publication year - 2010
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/0091270010376974
Subject(s) - mechanism (biology) , cotransporter , medicine , nanotechnology , engineering ethics , chemistry , sodium , engineering , epistemology , materials science , philosophy , organic chemistry
Advances in experimental medicine and technological innovation during the past century have brought tremendous progress in modern medicine and generated an ever‐increasing amount of data from bench and bedside. The desire to extend scientific knowledge motivates effective data integration. Technological innovation makes this possible, which in turn accelerates the advancement in science. This mutually beneficial interaction is illustrated by the development of an expanded mechanism‐based model for understanding a novel mechanism, sodium‐glucose cotransporter‐2 SGLT2 inhibition for potential treatment of type 2 diabetes mellitus.